pentobarbital will minimize the extent or result of voriconazole by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Mysterious.
Barbiturates can induce hepatic microsomal enzymes resulting in elevated metabolism and diminished anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); clients stabilized on anticoagulant therapy may demand dosage changes if barbiturates are included to or withdrawn from their dosage regimen
pentobarbital will minimize the extent or influence of irinotecan liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the level or effect of docetaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.
pentobarbital will lower the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Watch Intently (1)pentobarbital will lessen the extent or impact of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or influence of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.
pentobarbital will reduce the extent or effect of iloperidone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital increases toxicity of methoxyflurane by increasing metabolism. Contraindicated. Increased metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will decrease the extent or impact of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.
pentobarbital will lower the extent or influence of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
buprenorphine subdermal implant and pentobarbital both maximize sedation. Stay clear of or Use Alternate Drug. Restrict use to sufferers for whom substitute therapy solutions are insufficient
Parenteral alternatives of barbiturates are highly alkaline; Serious treatment must be taken in order to avoid perivascular extravasation or intra-arterial injection; extravascular injection may trigger regional tissue destruction with subsequent necrosis; implications of intra-arterial injection may perhaps vary from transient pain to gangrene from the limb; any criticism of ache within the limb warrants stopping the injection
pentobarbital and olopatadine intranasal both boost sedation. Steer clear of or Use Alternate Drug. Coadministration boosts chance of CNS depression, which can lead to additive impairment of here psychomotor effectiveness and trigger daytime impairment.